Cation Interdiffusion in Squid Giant Axons

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Cation Interdiffusion in Squid Giant Axons

Radiotracer techniques were used to study the influxes and effluxes of various univalent cations in internally perfused squid giant axons. Membrane currents and conductances were determined by the voltage-clamp technique under analogous internal and external conditions. Both sodium-containing and sodium-free internal and external media were studied. Membrane impedance was measured with an ac im...

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Sodium Movements in Perfused Squid Giant Axons

Sodium movements in internally perfused giant axons from the squid Dosidicus gigas were studied with varying internal sodium concentrations and with fluoride as the internal anion. It was found that as the internal concentration of sodium was increased from 2 to 200 mM the resting sodium efflux increased from 0.09 to 34.0 pmoles/cm(2)sec and the average resting sodium influx increased from 42.9...

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Multimodal transition and stochastic antiresonance in squid giant axons.

The experimental data of Takahashi [Physica D 43, 318 (1990)], on the response of squid giant axons stimulated by periodic sequence of short current pulses is interpreted within the Hodgkin-Huxley model. The minimum of the firing rate as a function of the stimulus amplitude I0 in the high-frequency regime is due to the multimodal transition. Below this singular point only odd multiples of the d...

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Calcium Content and Net Fluxes in Squid Giant Axons

Axons freshly dissected from living specimens of the tropical squid Dorytheutis plei have a calcium content of 68 tzmol/kg of axoplasm. Fibers stimulated at 100 impuises/s in 100 mM Ca seawater increase their Ca content by 150/zmol/ kg.min; axons placed in 3 Ca (choline) seawater increase their Ca content by 12 /zmol/kg.min. Axons loaded with 0.2-1.5 mmol Ca/kg of axoplasm extruded Ca with a ha...

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Magnesium content and net fluxes in squid giant axons

The Mg content of axons freshly dissected from living specimens of the tropical squid Doryteuthis plei was determined by atomic absorption spectroscopy to be 4.2 +/- 0.2 mmol/kg axoplasm. The axon's ability to maintain this physiological content of total intracellular Mg([Mg]i) was studied. Mgi was shown to be a linear function of Mgo when Mgo of incubating fluid was varied between 0 and 250 mM...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 1967

ISSN: 1540-7748,0022-1295

DOI: 10.1085/jgp.50.4.989